XNAS 11 Jul, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 07 Jul 2025 | 6,244 | 100,137 (0%) | 0% | 19.7 | 123,257 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 6,244 | 18,880 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 4,362 | 0 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 23,565 | 15,710 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jul 2025 | 13,717 | 12,023 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 96.19 per share. | 07 Jul 2025 | 22,181 | 84,017 (0%) | 0% | 96.2 | 2,133,590 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 95.66 per share. | 07 Jul 2025 | 35,583 | 106,198 (0%) | 0% | 95.7 | 3,403,870 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 07 Jul 2025 | 13,717 | 141,781 (0%) | 0% | 26.5 | 362,952 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.43 per share. | 07 Jul 2025 | 23,565 | 128,064 (0%) | 0% | 26.4 | 622,823 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.70 per share. | 07 Jul 2025 | 4,362 | 104,499 (0%) | 0% | 24.7 | 107,741 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 01 Jul 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2025 | 6,830 | 20,525 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 99.61 per share. | 01 Jul 2025 | 815 | 233,924 (0%) | 0% | 99.6 | 81,182 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 98.83 per share. | 01 Jul 2025 | 2,349 | 234,739 (0%) | 0% | 98.8 | 232,152 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 97.73 per share. | 01 Jul 2025 | 3,666 | 237,088 (0%) | 0% | 97.7 | 358,278 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 23 Jun 2025 | 35,253 | 138,665 (0%) | 0% | 18.9 | 668,044 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jun 2025 | 12,636 | 25,124 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Jun 2025 | 35,253 | 99,007 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 102.15 per share. | 23 Jun 2025 | 8,661 | 93,536 (0%) | 0% | 102.1 | 884,721 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 101.71 per share. | 23 Jun 2025 | 49,104 | 102,197 (0%) | 0% | 101.7 | 4,994,368 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.74 per share. | 23 Jun 2025 | 12,636 | 151,301 (0%) | 0% | 19.7 | 249,435 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 99.65 per share. | 16 Jun 2025 | 1,558 | 306,758 (0%) | 0% | 99.7 | 155,255 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 100.70 per share. | 16 Jun 2025 | 2,300 | 304,458 (0%) | 0% | 100.7 | 231,610 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 98.51 per share. | 16 Jun 2025 | 442 | 308,316 (0%) | 0% | 98.5 | 43,541 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Jun 2025 | 129,805 | 27,355 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 101.23 per share. | 16 Jun 2025 | 41,784 | 233,924 (0%) | 0% | 101.2 | 4,229,794 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 100.54 per share. | 16 Jun 2025 | 48,531 | 275,708 (0%) | 0% | 100.5 | 4,879,307 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 99.51 per share. | 16 Jun 2025 | 32,490 | 324,239 (0%) | 0% | 99.5 | 3,233,080 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 98.50 per share. | 16 Jun 2025 | 7,000 | 356,729 (0%) | 0% | 98.5 | 689,500 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 16 Jun 2025 | 129,805 | 363,729 (0%) | 0% | 10.8 | 1,408,384 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 101.39 per share. | 16 Jun 2025 | 904 | 303,554 (0%) | 0% | 101.4 | 91,657 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 99.32 per share. | 16 Jun 2025 | 4,186 | 130,637 (0%) | 0% | 99.3 | 415,754 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 98.50 per share. | 16 Jun 2025 | 6,500 | 134,823 (0%) | 0% | 98.5 | 640,250 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 90.93 per share. | 10 Jun 2025 | 6,328 | 103,512 (0%) | 0% | 90.9 | 575,405 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 89.85 per share. | 10 Jun 2025 | 15,825 | 109,840 (0%) | 0% | 89.8 | 1,421,876 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.99 per share. | 10 Jun 2025 | 20,926 | 125,665 (0%) | 0% | 89.0 | 1,862,205 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 88.29 per share. | 10 Jun 2025 | 7,310 | 146,591 (0%) | 0% | 88.3 | 645,400 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 87.12 per share. | 10 Jun 2025 | 7,277 | 153,901 (0%) | 0% | 87.1 | 633,972 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 10 Jun 2025 | 23,740 | 161,178 (0%) | 0% | 17.1 | 405,242 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 10 Jun 2025 | 24,150 | 137,438 (0%) | 0% | 19.0 | 457,643 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 23,740 | 35,610 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 24,150 | 134,260 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 91.66 per share. | 10 Jun 2025 | 100 | 103,412 (0%) | 0% | 91.7 | 9,166 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 19,423 | 64,744 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 25,740 | 17,160 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 94.50 per share. | 10 Jun 2025 | 19,423 | 83,111 (0%) | 0% | 94.5 | 1,835,474 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 10 Jun 2025 | 19,423 | 102,534 (0%) | 0% | 17.1 | 331,551 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 88.64 per share. | 10 Jun 2025 | 25,740 | 83,111 (0%) | 0% | 88.6 | 2,281,594 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 10 Jun 2025 | 25,740 | 108,851 (0%) | 0% | 26.5 | 681,080 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 10 Jun 2025 | 38,300 | 156,879 (0%) | 0% | 17.2 | 657,228 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 70,000 | 87,290 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2025 | 38,300 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 92.73 per share. | 10 Jun 2025 | 18,319 | 135,188 (0%) | 0% | 92.7 | 1,698,721 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 96.02 per share. | 10 Jun 2025 | 500 | 89,407 (0%) | 0% | 96.0 | 48,010 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 95.49 per share. | 10 Jun 2025 | 34,500 | 89,907 (0%) | 0% | 95.5 | 3,294,405 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 93.48 per share. | 10 Jun 2025 | 10,781 | 124,407 (0%) | 0% | 93.5 | 1,007,808 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 91.68 per share. | 10 Jun 2025 | 35,072 | 153,507 (0%) | 0% | 91.7 | 3,215,401 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.91 per share. | 10 Jun 2025 | 70,000 | 188,579 (0%) | 0% | 13.9 | 973,700 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 88.64 per share. | 10 Jun 2025 | 38,300 | 118,579 (0%) | 0% | 88.6 | 3,394,912 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 73.50 per share. | 05 Jun 2025 | 1,879 | 67,718 (0%) | 0% | 73.5 | 138,107 | Common Stock |
| David W.J. McGirr | Director | Sale of securities on an exchange or to another person at price $ 73.27 per share. | 03 Jun 2025 | 3,000 | 97,723 (0%) | 0% | 73.3 | 219,810 | Common Stock |
| David W.J. McGirr | Director | Sale of securities on an exchange or to another person at price $ 71.30 per share. | 03 Jun 2025 | 3,250 | 100,723 (0%) | 0% | 71.3 | 231,725 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,642 | 118,579 (0%) | 0% | 71.5 | 117,403 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,579 | 113,288 (0%) | 0% | 71.5 | 112,899 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,860 | 141,323 (0%) | 0% | 71.5 | 132,990 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,686 | 83,111 (0%) | 0% | 71.5 | 120,549 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 03 Jun 2025 | 1,448 | 69,597 (0%) | 0% | 71.5 | 103,532 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 02 Jun 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jun 2025 | 6,830 | 157,160 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.50 per share. | 02 Jun 2025 | 5,472 | 308,758 (0%) | 0% | 71.5 | 391,248 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.94 per share. | 02 Jun 2025 | 1,430 | 233,924 (0%) | 0% | 71.9 | 102,874 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.35 per share. | 02 Jun 2025 | 4,400 | 235,354 (0%) | 0% | 71.4 | 313,940 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 70.23 per share. | 02 Jun 2025 | 1,000 | 239,754 (0%) | 0% | 70.2 | 70,230 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 70.00 per share. | 30 May 2025 | 20,000 | 71,045 (0%) | 0% | 70 | 1,400,000 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 68.56 per share. | 30 May 2025 | 6,327 | 91,045 (0%) | 0% | 68.6 | 433,779 | Common Stock |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 27 May 2025 | 200 | 300,616 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 400 | 300,816 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2025 | 100 | 100 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 May 2025 | 6,830 | 163,990 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 68.54 per share. | 20 May 2025 | 1,716 | 233,924 (0%) | 0% | 68.5 | 117,615 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 68.13 per share. | 20 May 2025 | 2,251 | 235,640 (0%) | 0% | 68.1 | 153,361 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 66.90 per share. | 20 May 2025 | 2,863 | 237,891 (0%) | 0% | 66.9 | 191,535 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 20 May 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 68.49 per share. | 20 May 2025 | 7,088 | 314,230 (0%) | 0% | 68.5 | 485,457 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 67.96 per share. | 20 May 2025 | 4,480 | 321,318 (0%) | 0% | 68.0 | 304,461 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 66.87 per share. | 20 May 2025 | 9,489 | 325,798 (0%) | 0% | 66.9 | 634,529 | Common Stock |
| Clarissa Desjardins | Director | Purchase of securities on an exchange or from another person at price $ 66.87 per share. | 20 May 2025 | 1,895 | 1,895 (0%) | 0% | 66.9 | 126,719 | Common Stock |
| Clarissa Desjardins | Director | Purchase of securities on an exchange or from another person at price $ 66.35 per share. | 20 May 2025 | 1,130 | 3,025 (0%) | 0% | 66.4 | 74,976 | Common Stock |
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 63,317 (0%) | 0% | - | Common Stock | |
| David W.J. McGirr | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 103,973 (0%) | 0% | - | Common Stock | |
| Melvin Sharoky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 301,216 (0%) | 0% | - | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,578 | 120,221 (0%) | 0% | 0 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 27,100 | 27,100 | - | - | Stock Option (right to buy) | |
| David R. Brennan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 126,933 (0%) | 0% | - | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 22,314 | 335,287 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 108,380 | 108,380 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 31,610 | 31,610 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 6,508 | 114,867 (0%) | 0% | 0 | Common Stock | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 6,508 | 143,183 (0%) | 0% | 0 | Common Stock | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 31,610 | 31,610 | - | - | Stock Option (right to buy) | |
| Clarissa Desjardins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 67,007 (0%) | 0% | - | Common Stock | |
| Leo Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 129,677 (0%) | 0% | - | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,058 | 73,729 (0%) | 0% | - | Common Stock | |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 31,610 | 31,610 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 67.53 per share. | 15 May 2025 | 1,799 | 84,797 (0%) | 0% | 67.5 | 121,486 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.47 per share. | 15 May 2025 | 9,925 | 86,596 (0%) | 0% | 65.5 | 649,790 | Common Stock |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 6,508 | 96,521 (0%) | 0% | 0 | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 5,578 | 97,372 (0%) | 0% | 0 | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 May 2025 | 27,100 | 27,100 | - | - | Stock Option (right to buy) | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 14 May 2025 | 576 | 576 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 14 May 2025 | 576 | 296,158 (0%) | 0% | 0 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 65.61 per share. | 13 May 2025 | 1,236 | 114,643 (0%) | 0% | 65.6 | 81,094 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 67.81 per share. | 13 May 2025 | 4,999 | 115,879 (0%) | 0% | 67.8 | 338,982 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 65.61 per share. | 13 May 2025 | 3,771 | 312,973 (0%) | 0% | 65.6 | 247,415 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 66.40 per share. | 13 May 2025 | 9,743 | 324,443 (0%) | 0% | 66.4 | 646,935 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 67.70 per share. | 13 May 2025 | 7,699 | 316,744 (0%) | 0% | 67.7 | 521,222 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 65.61 per share. | 13 May 2025 | 1,634 | 108,359 (0%) | 0% | 65.6 | 107,207 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 67.81 per share. | 13 May 2025 | 8,870 | 109,993 (0%) | 0% | 67.8 | 601,475 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 65.61 per share. | 13 May 2025 | 1,925 | 136,675 (0%) | 0% | 65.6 | 126,299 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 67.81 per share. | 13 May 2025 | 7,482 | 138,600 (0%) | 0% | 67.8 | 507,354 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.61 per share. | 13 May 2025 | 1,744 | 90,013 (0%) | 0% | 65.6 | 114,424 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 67.81 per share. | 13 May 2025 | 8,408 | 91,757 (0%) | 0% | 67.8 | 570,146 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 67.81 per share. | 13 May 2025 | 4,407 | 92,203 (0%) | 0% | 67.8 | 298,839 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 65.61 per share. | 13 May 2025 | 409 | 91,794 (0%) | 0% | 65.6 | 26,834 | Common Stock |
| H. William Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 72.78 per share. | 01 May 2025 | 4,201 | 233,924 (0%) | 0% | 72.8 | 305,749 | Common Stock |
| Lewis William H. | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2025 | 6,830 | 170,820 | - | - | Stock Option (right to buy) | |
| Lewis William H. | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 72.24 per share. | 01 May 2025 | 2,629 | 238,125 (0%) | 0% | 72.2 | 189,919 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 01 May 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2025 | 6,830 | 177,650 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.30 per share. | 15 Apr 2025 | 600 | 233,924 (0%) | 0% | 71.3 | 42,780 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 70.54 per share. | 15 Apr 2025 | 2,896 | 234,524 (0%) | 0% | 70.5 | 204,284 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 69.62 per share. | 15 Apr 2025 | 3,334 | 237,420 (0%) | 0% | 69.6 | 232,113 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 15 Apr 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 75.26 per share. | 01 Apr 2025 | 805 | 233,924 (0%) | 0% | 75.3 | 60,584 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 74.78 per share. | 01 Apr 2025 | 2,232 | 234,729 (0%) | 0% | 74.8 | 166,909 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 73.44 per share. | 01 Apr 2025 | 772 | 236,961 (0%) | 0% | 73.4 | 56,696 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 72.29 per share. | 01 Apr 2025 | 3,021 | 237,733 (0%) | 0% | 72.3 | 218,388 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 01 Apr 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2025 | 6,830 | 184,480 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 77.83 per share. | 17 Mar 2025 | 2,737 | 233,924 (0%) | 0% | 77.8 | 213,021 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 77.01 per share. | 17 Mar 2025 | 2,070 | 236,661 (0%) | 0% | 77.0 | 159,411 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 76.00 per share. | 17 Mar 2025 | 2,023 | 238,731 (0%) | 0% | 76 | 153,748 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 17 Mar 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 77.79 per share. | 17 Mar 2025 | 8,116 | 334,186 (0%) | 0% | 77.8 | 631,344 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 76.87 per share. | 17 Mar 2025 | 5,907 | 342,302 (0%) | 0% | 76.9 | 454,071 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 75.91 per share. | 17 Mar 2025 | 4,727 | 348,209 (0%) | 0% | 75.9 | 358,827 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 17 Mar 2025 | 18,750 | 352,936 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2025 | 6,830 | 191,310 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2025 | 18,750 | 0 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 03 Mar 2025 | 18,750 | 352,936 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 6,830 | 198,140 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Mar 2025 | 18,750 | 18,750 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 80.89 per share. | 03 Mar 2025 | 46 | 233,924 (0%) | 0% | 80.9 | 3,721 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 79.73 per share. | 03 Mar 2025 | 377 | 233,970 (0%) | 0% | 79.7 | 30,058 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 78.97 per share. | 03 Mar 2025 | 2,250 | 234,347 (0%) | 0% | 79.0 | 177,683 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 78.20 per share. | 03 Mar 2025 | 1,486 | 236,597 (0%) | 0% | 78.2 | 116,205 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 76.23 per share. | 03 Mar 2025 | 2,671 | 238,083 (0%) | 0% | 76.2 | 203,610 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 03 Mar 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 03 Mar 2025 | 127 | 334,186 (0%) | 0% | 80.9 | 10,274 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 79.43 per share. | 03 Mar 2025 | 2,785 | 334,313 (0%) | 0% | 79.4 | 221,213 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 78.61 per share. | 03 Mar 2025 | 7,763 | 337,098 (0%) | 0% | 78.6 | 610,249 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 77.75 per share. | 03 Mar 2025 | 758 | 344,861 (0%) | 0% | 77.8 | 58,935 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 76.24 per share. | 03 Mar 2025 | 7,317 | 345,619 (0%) | 0% | 76.2 | 557,848 | Common Stock |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2025 | 481 | 4,764 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2025 | 481 | 3,481 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2025 | 481 | 5,180 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 25 Feb 2025 | 1,443 | 296,734 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 79.95 per share. | 18 Feb 2025 | 1,253 | 351,683 (0%) | 0% | 79.9 | 100,177 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 81.08 per share. | 18 Feb 2025 | 16,743 | 334,940 (0%) | 0% | 81.1 | 1,357,522 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 18 Feb 2025 | 18,750 | 352,936 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 6,830 | 204,970 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2025 | 18,750 | 37,500 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 81.81 per share. | 18 Feb 2025 | 300 | 233,924 (0%) | 0% | 81.8 | 24,543 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 81.07 per share. | 18 Feb 2025 | 6,074 | 234,224 (0%) | 0% | 81.1 | 492,419 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 18 Feb 2025 | 456 | 240,298 (0%) | 0% | 80 | 36,480 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 18 Feb 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 81.67 per share. | 18 Feb 2025 | 754 | 334,186 (0%) | 0% | 81.7 | 61,579 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 18 Feb 2025 | 700 | 118,863 (0%) | 0% | 81 | 56,700 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.28 per share. | 18 Feb 2025 | 17,622 | 119,563 (0%) | 0% | 80.3 | 1,414,694 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 11 Feb 2025 | 13,302 | 142,204 (0%) | 0% | 80 | 1,064,160 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 11 Feb 2025 | 5,019 | 137,185 (0%) | 0% | 80 | 401,520 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 10 Feb 2025 | 26,141 | 146,082 (0%) | 0% | 79.3 | 2,073,766 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 78.36 per share. | 10 Feb 2025 | 5,781 | 172,223 (0%) | 0% | 78.4 | 452,999 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 77.02 per share. | 10 Feb 2025 | 11,053 | 178,004 (0%) | 0% | 77.0 | 851,302 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 77.02 per share. | 10 Feb 2025 | 9,729 | 128,264 (0%) | 0% | 77.0 | 749,328 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 79.33 per share. | 10 Feb 2025 | 23,010 | 100,165 (0%) | 0% | 79.3 | 1,825,383 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 78.36 per share. | 10 Feb 2025 | 5,089 | 123,175 (0%) | 0% | 78.4 | 398,774 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2025 | 47,295 | 144,378 (0%) | 0% | 0 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 05 Feb 2025 | 23,500 | 120,878 (0%) | 0% | 80.9 | 1,901,150 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2025 | 153,710 | 533,244 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 05 Feb 2025 | 79,350 | 453,894 (0%) | 0% | 80.9 | 6,419,415 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 05 Feb 2025 | 28,390 | 155,506 (0%) | 0% | 80.9 | 2,296,751 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2025 | 65,033 | 183,896 (0%) | 0% | 0 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2025 | 15,373 | 140,935 (0%) | 0% | 0 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 78.90 per share. | 05 Feb 2025 | 10 | 133,015 (0%) | 0% | 78.9 | 789 | Common Stock |
| Drayton Wise | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 05 Feb 2025 | 7,910 | 133,025 (0%) | 0% | 80.9 | 639,919 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 05 Feb 2025 | 45,605 | 189,157 (0%) | 0% | 80.9 | 3,689,445 | Common Stock |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2025 | 88,680 | 234,762 (0%) | 0% | 0 | Common Stock | |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 79.57 per share. | 05 Feb 2025 | 100 | 189,057 (0%) | 0% | 79.6 | 7,957 | Common Stock |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2025 | 70,943 | 171,108 (0%) | 0% | 0 | Common Stock | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 79.58 per share. | 05 Feb 2025 | 60 | 137,993 (0%) | 0% | 79.6 | 4,775 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 05 Feb 2025 | 33,055 | 138,053 (0%) | 0% | 80.9 | 2,674,150 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 80.90 per share. | 05 Feb 2025 | 20,650 | 96,610 (0%) | 0% | 80.9 | 1,670,585 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Feb 2025 | 47,295 | 117,260 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 77.97 per share. | 03 Feb 2025 | 9,869 | 386,302 (0%) | 0% | 78.0 | 769,486 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 6,830 | 211,800 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Feb 2025 | 18,750 | 56,250 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 78.40 per share. | 03 Feb 2025 | 2,581 | 233,924 (0%) | 0% | 78.4 | 202,350 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 77.95 per share. | 03 Feb 2025 | 3,463 | 236,505 (0%) | 0% | 78.0 | 269,941 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 76.43 per share. | 03 Feb 2025 | 745 | 239,968 (0%) | 0% | 76.4 | 56,940 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 74.85 per share. | 03 Feb 2025 | 41 | 240,713 (0%) | 0% | 74.9 | 3,069 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 03 Feb 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 78.44 per share. | 03 Feb 2025 | 6,768 | 379,534 (0%) | 0% | 78.4 | 530,882 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 03 Feb 2025 | 18,750 | 398,284 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 75.25 per share. | 03 Feb 2025 | 241 | 398,043 (0%) | 0% | 75.2 | 18,135 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 76.35 per share. | 03 Feb 2025 | 1,872 | 396,171 (0%) | 0% | 76.3 | 142,927 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.16 per share. | 30 Jan 2025 | 50,000 | 147,083 (0%) | 0% | 16.2 | 808,000 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 41,140 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 50,000 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 80.00 per share. | 30 Jan 2025 | 91,140 | 97,083 (0%) | 0% | 80 | 7,291,200 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.67 per share. | 30 Jan 2025 | 41,140 | 188,223 (0%) | 0% | 13.7 | 562,384 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 69.40 per share. | 15 Jan 2025 | 1,499 | 239,255 (0%) | 0% | 69.4 | 104,031 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 15 Jan 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 70.31 per share. | 15 Jan 2025 | 4,700 | 234,555 (0%) | 0% | 70.3 | 330,457 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 6,830 | 218,630 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2025 | 18,750 | 75,000 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.01 per share. | 15 Jan 2025 | 631 | 233,924 (0%) | 0% | 71.0 | 44,807 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 15 Jan 2025 | 18,750 | 411,339 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 69.39 per share. | 15 Jan 2025 | 6,636 | 404,703 (0%) | 0% | 69.4 | 460,472 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 70.32 per share. | 15 Jan 2025 | 22,696 | 382,007 (0%) | 0% | 70.3 | 1,595,983 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 71.05 per share. | 15 Jan 2025 | 2,473 | 379,534 (0%) | 0% | 71.1 | 175,707 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 68.72 per share. | 14 Jan 2025 | 872 | 97,083 (0%) | 0% | 68.7 | 59,924 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 68.72 per share. | 14 Jan 2025 | 1,457 | 146,082 (0%) | 0% | 68.7 | 100,125 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 68.72 per share. | 14 Jan 2025 | 1,384 | 100,165 (0%) | 0% | 68.7 | 95,108 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 02 Jan 2025 | 18,750 | 403,710 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 69.84 per share. | 02 Jan 2025 | 18,750 | 384,960 (0%) | 0% | 69.8 | 1,309,500 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 02 Jan 2025 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 69.86 per share. | 02 Jan 2025 | 6,830 | 233,924 (0%) | 0% | 69.9 | 477,144 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 18,750 | 93,750 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 6,830 | 225,460 | - | - | Stock Option (right to buy) | |
| H. Lewis William | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 19 Dec 2024 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| William Lewis H. | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 69.71 per share. | 19 Dec 2024 | 5,240 | 235,514 (0%) | 0% | 69.7 | 365,280 | Common Stock |
| William Lewis H. | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 69.65 per share. | 19 Dec 2024 | 13,162 | 390,548 (0%) | 0% | 69.6 | 916,733 | Common Stock |
| William Lewis H. | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2024 | 18,750 | 112,500 | - | - | Stock Option (right to buy) | |
| H. William Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 70.61 per share. | 19 Dec 2024 | 1,590 | 233,924 (0%) | 0% | 70.6 | 112,270 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2024 | 6,830 | 232,290 | - | - | Stock Option (right to buy) | |
| Lewis William H. | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 19 Dec 2024 | 18,750 | 403,710 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 70.52 per share. | 19 Dec 2024 | 5,588 | 384,960 (0%) | 0% | 70.5 | 394,066 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 72.57 per share. | 12 Dec 2024 | 4,087 | 236,667 (0%) | 0% | 72.6 | 296,594 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2024 | 6,830 | 239,120 | - | - | Stock Option (right to buy) | |
| Lewis H. William | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 12 Dec 2024 | 18,750 | 403,710 (0%) | 0% | 22.8 | 426,750 | Common Stock |
| Lewis William H. | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 74.22 per share. | 12 Dec 2024 | 181 | 233,924 (0%) | 0% | 74.2 | 13,434 | Common Stock |
| H. Lewis William | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 74.23 per share. | 12 Dec 2024 | 399 | 384,960 (0%) | 0% | 74.2 | 29,618 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2024 | 18,750 | 131,250 | - | - | Stock Option (right to buy) | |
| Lewis William H. | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 12 Dec 2024 | 6,830 | 240,754 (0%) | 0% | 10.9 | 74,106 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 73.55 per share. | 12 Dec 2024 | 2,562 | 234,105 (0%) | 0% | 73.5 | 188,435 | Common Stock |
| H. William Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 72.58 per share. | 12 Dec 2024 | 11,504 | 392,206 (0%) | 0% | 72.6 | 834,960 | Common Stock |
| William Lewis H. | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 73.56 per share. | 12 Dec 2024 | 6,847 | 385,359 (0%) | 0% | 73.6 | 503,665 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 13 Sep 2024 | 7,000 | 95,727 (0%) | 0% | 22.8 | 159,320 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Sep 2024 | 7,000 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 74.75 per share. | 13 Sep 2024 | 9,000 | 67,856 (0%) | 0% | 74.8 | 672,750 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 74.16 per share. | 13 Sep 2024 | 18,871 | 76,856 (0%) | 0% | 74.2 | 1,399,473 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2024 | 13,436 | 13,680 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.03 per share. | 12 Sep 2024 | 13,436 | 119,570 (0%) | 0% | 34.0 | 457,227 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 74.90 per share. | 12 Sep 2024 | 26,969 | 106,134 (0%) | 0% | 74.9 | 2,019,978 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.03 per share. | 12 Sep 2024 | 26,969 | 133,103 (0%) | 0% | 34.0 | 917,755 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 74.92 per share. | 12 Sep 2024 | 635 | 106,134 (0%) | 0% | 74.9 | 47,574 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.03 per share. | 12 Sep 2024 | 635 | 106,769 (0%) | 0% | 34.0 | 21,609 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2024 | 26,969 | 27,116 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Sep 2024 | 635 | 54,085 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 74.92 per share. | 12 Sep 2024 | 13,436 | 106,134 (0%) | 0% | 74.9 | 1,006,625 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 71.37 per share. | 10 Sep 2024 | 27,993 | 109,682 (0%) | 0% | 71.4 | 1,997,860 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 10 Sep 2024 | 37,575 | 137,675 (0%) | 0% | 10.9 | 407,689 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2024 | 37,575 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 71.88 per share. | 10 Sep 2024 | 9,582 | 100,100 (0%) | 0% | 71.9 | 688,754 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 18.95 per share. | 06 Sep 2024 | 36,555 | 142,689 (0%) | 0% | 18.9 | 692,717 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 72.61 per share. | 06 Sep 2024 | 9,064 | 106,134 (0%) | 0% | 72.6 | 658,137 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2024 | 36,555 | 109,665 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2024 | 25,740 | 42,900 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2024 | 18,874 | 0 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2024 | 34,280 | 34,280 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2024 | 14,130 | 0 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2024 | 19,423 | 84,167 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 71.43 per share. | 06 Sep 2024 | 63,483 | 115,198 (0%) | 0% | 71.4 | 4,534,591 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 70.90 per share. | 06 Sep 2024 | 76,455 | 178,681 (0%) | 0% | 70.9 | 5,420,660 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 06 Sep 2024 | 19,423 | 255,136 (0%) | 0% | 17.1 | 331,551 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.75 per share. | 06 Sep 2024 | 14,130 | 235,713 (0%) | 0% | 23.8 | 335,588 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.43 per share. | 06 Sep 2024 | 34,280 | 221,583 (0%) | 0% | 26.4 | 906,020 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.66 per share. | 06 Sep 2024 | 18,874 | 187,303 (0%) | 0% | 23.7 | 446,559 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 06 Sep 2024 | 25,740 | 168,429 (0%) | 0% | 26.5 | 681,080 | Common Stock |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 29 Aug 2024 | 10,000 | 298,177 (0%) | 0% | 0 | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 29 Aug 2024 | 10,000 | 17,714 (0%) | 0% | 0 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 72.49 per share. | 12 Aug 2024 | 9,469 | 100,100 (0%) | 0% | 72.5 | 686,408 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 34,530 | 34,530 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 41,640 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Aug 2024 | 11,900 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 73.65 per share. | 12 Aug 2024 | 20,415 | 88,727 (0%) | 0% | 73.7 | 1,503,565 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 12 Aug 2024 | 34,530 | 176,797 (0%) | 0% | 17.1 | 589,427 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.91 per share. | 12 Aug 2024 | 41,640 | 142,267 (0%) | 0% | 13.9 | 579,212 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.16 per share. | 12 Aug 2024 | 11,900 | 100,627 (0%) | 0% | 17.2 | 204,204 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 72.75 per share. | 12 Aug 2024 | 67,655 | 109,142 (0%) | 0% | 72.7 | 4,921,901 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 70.05 per share. | 08 Jul 2024 | 730 | 88,727 (0%) | 0% | 70.1 | 51,137 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 10 Jun 2024 | 21,195 | 106,134 (0%) | 0% | 60 | 1,271,700 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.75 per share. | 10 Jun 2024 | 21,195 | 127,329 (0%) | 0% | 23.7 | 503,381 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2024 | 21,195 | 14,130 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.76 per share. | 03 Jun 2024 | 41,250 | 163,760 (0%) | 0% | 22.8 | 938,850 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 13,750 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.07 per share. | 03 Jun 2024 | 13,750 | 122,510 (0%) | 0% | 16.1 | 220,963 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 41,250 | 0 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 55.33 per share. | 03 Jun 2024 | 55,000 | 108,760 (0%) | 0% | 55.3 | 3,043,150 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.58 per share. | 28 May 2024 | 27,500 | 136,260 (0%) | 0% | 12.6 | 345,950 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 49.53 per share. | 28 May 2024 | 27,500 | 108,760 (0%) | 0% | 49.5 | 1,362,075 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 27,500 | 0 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.70 per share. | 28 May 2024 | 3,454 | 201,120 (0%) | 0% | 24.7 | 85,314 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.88 per share. | 28 May 2024 | 76,731 | 197,666 (0%) | 0% | 28.9 | 2,215,991 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 28.88 per share. | 28 May 2024 | 3,454 | 120,935 (0%) | 0% | 28.9 | 99,752 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 28 May 2024 | 3,454 | 260,148 (0%) | 0% | 26.5 | 91,393 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.03 per share. | 28 May 2024 | 3,454 | 231,648 (0%) | 0% | 34.0 | 117,540 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 24.70 per share. | 28 May 2024 | 27,074 | 228,194 (0%) | 0% | 24.7 | 668,728 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 76,731 | 11,455 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,454 | 88,186 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 28 May 2024 | 220,564 | 117,481 (0%) | 0% | 50 | 11,028,200 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 50.01 per share. | 28 May 2024 | 20,724 | 338,045 (0%) | 0% | 50.0 | 1,036,407 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 28 May 2024 | 32,156 | 358,769 (0%) | 0% | 17.1 | 548,903 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.07 per share. | 28 May 2024 | 3,454 | 326,613 (0%) | 0% | 17.1 | 58,960 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.43 per share. | 28 May 2024 | 20,111 | 323,159 (0%) | 0% | 26.4 | 531,534 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.43 per share. | 28 May 2024 | 3,454 | 303,048 (0%) | 0% | 26.4 | 91,289 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 26.46 per share. | 28 May 2024 | 39,446 | 299,594 (0%) | 0% | 26.5 | 1,043,741 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 34.03 per share. | 28 May 2024 | 25,046 | 256,694 (0%) | 0% | 34.0 | 852,315 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 32,156 | 59,350 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,454 | 91,506 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 20,111 | 39,275 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,454 | 59,386 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 39,446 | 25,740 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,454 | 65,186 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 25,046 | 17,100 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,454 | 42,146 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 27,074 | 4,362 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,454 | 31,436 | - | - | Stock Option (right to buy) | |
| Drayton Wise | Chief Commercial Officer | 28 May 2024 | 6,250 | 121,657 (0%) | 0% | 50 | 312,500 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 28 May 2024 | 6,250 | 127,907 (0%) | 0% | 12.6 | 78,625 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 28 May 2024 | 1,602 | 121,657 (0%) | 0% | 49.0 | 78,418 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 28 May 2024 | 6,250 | 0 | - | - | Stock Option (right to buy) | ||
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 103,806 | 18,874 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.75 per share. | 28 May 2024 | 21,195 | 127,329 (0%) | 0% | 23.7 | 503,381 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 21,195 | 35,325 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 49.62 per share. | 28 May 2024 | 103,806 | 106,134 (0%) | 0% | 49.6 | 5,150,854 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.66 per share. | 28 May 2024 | 103,806 | 209,940 (0%) | 0% | 23.7 | 2,456,050 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 55.00 per share. | 28 May 2024 | 21,195 | 106,134 (0%) | 0% | 55 | 1,165,725 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 7,000 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 14,810 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,470 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 3,691 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 May 2024 | 10,000 | 0 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 49.53 per share. | 28 May 2024 | 44,722 | 88,828 (0%) | 0% | 49.5 | 2,215,081 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 13.67 per share. | 28 May 2024 | 14,810 | 133,550 (0%) | 0% | 13.7 | 202,453 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 11.38 per share. | 28 May 2024 | 3,470 | 118,740 (0%) | 0% | 11.4 | 39,489 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 10.85 per share. | 28 May 2024 | 3,691 | 115,270 (0%) | 0% | 10.8 | 40,047 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.16 per share. | 28 May 2024 | 10,000 | 111,579 (0%) | 0% | 16.2 | 161,600 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.07 per share. | 28 May 2024 | 7,000 | 101,579 (0%) | 0% | 16.1 | 112,490 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.09 per share. | 17 May 2024 | 5,945 | 149,275 (0%) | 0% | 25.1 | 149,160 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.09 per share. | 17 May 2024 | 4,642 | 106,134 (0%) | 0% | 25.1 | 116,468 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 25.47 per share. | 13 May 2024 | 10,640 | 110,776 (0%) | 0% | 25.5 | 271,001 | Common Stock |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,308 | 99,672 (0%) | 0% | - | Common Stock | |
| Michael A. Smith | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 65,230 | 65,230 | - | - | Stock Option (right to buy) | |
| Michael A. Smith | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 25.40 per share. | 13 May 2024 | 5,093 | 94,579 (0%) | 0% | 25.4 | 129,362 | Common Stock |
| Alfred F. Altomari | Director | 13 May 2024 | 13,162 | 69,495 (0%) | 0% | - | Common Stock | ||
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,162 | 58,259 (0%) | 0% | - | Common Stock | |
| David W.J. McGirr | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,162 | 98,915 (0%) | 0% | - | Common Stock | |
| Melvin Sharoky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,162 | 308,177 (0%) | 0% | - | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,308 | 115,268 (0%) | 0% | - | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 65,230 | 65,230 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 25.53 per share. | 13 May 2024 | 6,508 | 108,760 (0%) | 0% | 25.5 | 166,149 | Common Stock |
| David R Brennan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,162 | 121,875 (0%) | 0% | - | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 25.52 per share. | 13 May 2024 | 22,198 | 384,125 (0%) | 0% | 25.5 | 566,493 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 42,707 | 406,323 (0%) | 0% | - | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 209,320 | 209,320 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 71,160 | 71,160 | - | - | Stock Option (right to buy) | |
| Sara M. Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.32 per share. | 13 May 2024 | 11,088 | 117,481 (0%) | 0% | 25.3 | 280,748 | Common Stock |
| Sara M. Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 14,518 | 128,569 (0%) | 0% | - | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 13 May 2024 | 5,088 | 123,259 (0%) | 0% | 25.5 | 129,591 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 13 May 2024 | 71,160 | 71,160 | - | - | Stock Option (right to buy) | ||
| Drayton Wise | Chief Commercial Officer | 13 May 2024 | 14,518 | 128,347 (0%) | 0% | - | Common Stock | ||
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 25.50 per share. | 13 May 2024 | 7,857 | 155,220 (0%) | 0% | 25.5 | 200,354 | Common Stock |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 71,160 | 71,160 | - | - | Stock Option (right to buy) | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 14,518 | 163,077 (0%) | 0% | - | Common Stock | |
| Clarissa Desjardins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,162 | 61,949 (0%) | 0% | - | Common Stock | |
| Leo Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,162 | 124,619 (0%) | 0% | - | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 13,162 | 68,671 (0%) | 0% | - | Common Stock | |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 71,160 | 71,160 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 May 2024 | 14,518 | 121,416 (0%) | 0% | - | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Feb 2024 | 3,600 | 295,015 (0%) | 0% | 0 | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.58 per share. | 28 Feb 2024 | 50,000 | 50,500 (0%) | 0% | 12.6 | 629,000 | Common Stock |
| H. William Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2024 | 50,000 | 0 | - | - | Stock Option (right to buy) | |
| Sharoky Melvin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Feb 2024 | 1,200 | 4,283 (0%) | 0% | 0 | Common Stock | |
| Sharoky Melvin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Feb 2024 | 1,200 | 3,000 (0%) | 0% | 0 | Common Stock | |
| Sharoky Melvin | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 28 Feb 2024 | 1,200 | 4,699 (0%) | 0% | 0 | Common Stock | |
| Adsett Roger | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 28.63 per share. | 12 Jan 2024 | 5,251 | 148,559 (0%) | 0% | 28.6 | 150,336 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.63 per share. | 12 Jan 2024 | 4,667 | 106,898 (0%) | 0% | 28.6 | 133,616 | Common Stock |
| Smith Michael | General Counsel, Senior VP | Sale of securities on an exchange or to another person at price $ 28.76 per share. | 09 Jan 2024 | 2,373 | 86,364 (0%) | 0% | 28.8 | 68,247 | Common Stock |
| Sara Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 29.18 per share. | 09 Jan 2024 | 4,497 | 114,051 (0%) | 0% | 29.2 | 131,222 | Common Stock |
| Adsett Roger | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 28.90 per share. | 09 Jan 2024 | 3,536 | 153,810 (0%) | 0% | 28.9 | 102,190 | Common Stock |
| S. Schaeffer Nicole | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jan 2024 | 503 | 0 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.01 per share. | 09 Jan 2024 | 4,715 | 112,810 (0%) | 0% | 29.0 | 136,782 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.25 per share. | 09 Jan 2024 | 3,837 | 157,346 (0%) | 0% | 29.2 | 112,232 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.49 per share. | 09 Jan 2024 | 503 | 105,652 (0%) | 0% | 20.5 | 10,306 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 29.56 per share. | 09 Jan 2024 | 503 | 105,149 (0%) | 0% | 29.6 | 14,869 | Common Stock |
| Drayton Wise | Chief Commercial Officer | 09 Jan 2024 | 1,861 | 113,829 (0%) | 0% | 28.8 | 53,560 | Common Stock | |
| Schaeffer Nicole S. | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 28.74 per share. | 09 Jan 2024 | 3,165 | 101,984 (0%) | 0% | 28.7 | 90,962 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.90 per share. | 09 Jan 2024 | 1,245 | 111,565 (0%) | 0% | 28.9 | 35,981 | Common Stock |
| Lewis William H. | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jan 2024 | 45,120 | 0 | - | - | Stock Option (right to buy) | |
| William Lewis H. | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 28.72 per share. | 08 Jan 2024 | 9,887 | 363,651 (0%) | 0% | 28.7 | 283,955 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.49 per share. | 08 Jan 2024 | 20,169 | 393,707 (0%) | 0% | 20.5 | 413,263 | Common Stock |
| H. William Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.49 per share. | 08 Jan 2024 | 24,951 | 398,489 (0%) | 0% | 20.5 | 511,246 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 29.11 per share. | 08 Jan 2024 | 24,951 | 373,538 (0%) | 0% | 29.1 | 726,324 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 29.88 per share. | 08 Jan 2024 | 20,169 | 373,538 (0%) | 0% | 29.9 | 602,650 | Common Stock |
| Lewis H. William | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 186,970 | 186,970 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 11,800 | 106,606 (0%) | 0% | - | Common Stock | |
| S. Schaeffer Nicole | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 29.28 per share. | 04 Jan 2024 | 1,457 | 105,149 (0%) | 0% | 29.3 | 42,661 | Common Stock |
| H. Lewis William | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 29.26 per share. | 04 Jan 2024 | 6,979 | 373,538 (0%) | 0% | 29.3 | 204,195 | Common Stock |
| Flammer Martina | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 63,560 | 63,560 | - | - | Stock Option (right to buy) | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 12,873 | 164,225 (0%) | 0% | - | Common Stock | |
| Michael Smith | General Counsel, Senior VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 58,260 | 58,260 | - | - | Stock Option (right to buy) | |
| Martina Flammer | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 12,873 | 118,911 (0%) | 0% | - | Common Stock | |
| Michael Smith | General Counsel, Senior VP | Sale of securities on an exchange or to another person at price $ 29.30 per share. | 04 Jan 2024 | 627 | 88,737 (0%) | 0% | 29.3 | 18,374 | Common Stock |
| Smith Michael | General Counsel, Senior VP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 11,800 | 89,364 (0%) | 0% | - | Common Stock | |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 29.21 per share. | 04 Jan 2024 | 3,042 | 161,183 (0%) | 0% | 29.2 | 88,864 | Common Stock |
| Schaeffer S. Nicole | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 58,260 | 58,260 | - | - | Stock Option (right to buy) | |
| Adsett Roger | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 63,560 | 63,560 | - | - | Stock Option (right to buy) | |
| Sara Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 12,873 | 118,548 (0%) | 0% | - | Common Stock | |
| Flammer Martina | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 29.20 per share. | 04 Jan 2024 | 1,386 | 117,525 (0%) | 0% | 29.2 | 40,478 | Common Stock |
| Sara Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 63,560 | 63,560 | - | - | Stock Option (right to buy) | |
| Lewis H. William | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Jan 2024 | 37,869 | 380,517 (0%) | 0% | - | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 03 Jan 2024 | 20,071 | 0 | - | - | Stock Option (right to buy) | ||
| Wise Drayton | Chief Commercial Officer | 03 Jan 2024 | 1,167 | 115,690 (0%) | 0% | 29.3 | 34,216 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 03 Jan 2024 | 20,071 | 124,055 | - | 19.1 | 383,557 | Stock Option (right to buy) | |
| Wise Drayton | Chief Commercial Officer | 03 Jan 2024 | 63,560 | 63,560 | - | - | Stock Option (right to buy) | ||
| Wise Drayton | Chief Commercial Officer | 03 Jan 2024 | 20,071 | 103,984 | - | 29.2 | 585,872 | Stock Option (right to buy) | |
| Wise Drayton | Chief Commercial Officer | 03 Jan 2024 | 12,873 | 116,857 (0%) | 0% | - | Common Stock | ||
| Schaeffer Nicole S. | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Dec 2023 | 22,288 | 503 | - | - | Stock Option (right to buy) | |
| Schaeffer Nicole S. | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 32.00 per share. | 28 Dec 2023 | 22,288 | 94,549 (0%) | 0% | 32 | 713,216 | Common Stock |
| Nicole Schaeffer S. | Chief People Strategy Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.49 per share. | 28 Dec 2023 | 22,288 | 116,837 (0%) | 0% | 20.5 | 456,681 | Common Stock |
| Flammer Martina | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 22 Dec 2023 | 28,310 | 106,038 (0%) | 0% | 30 | 849,300 | Common Stock |
| Flammer Martina | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.66 per share. | 22 Dec 2023 | 28,310 | 134,348 (0%) | 0% | 23.7 | 669,815 | Common Stock |
| Bonstein Sara | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 22 Dec 2023 | 13,199 | 105,241 (0%) | 0% | 30 | 395,970 | Common Stock |
| Martina Flammer | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Dec 2023 | 28,310 | 122,680 | - | - | Stock Option (right to buy) | |
| Michael Smith | General Counsel, Senior VP | Sale of securities on an exchange or to another person at price $ 20.18 per share. | 11 Jul 2023 | 740 | 77,142 (0%) | 0% | 20.2 | 14,933 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.32 per share. | 13 Jun 2023 | 8,981 | 151,352 (0%) | 0% | 19.3 | 173,513 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 19.27 per share. | 13 Jun 2023 | 8,868 | 106,038 (0%) | 0% | 19.3 | 170,886 | Common Stock |
| Drayton Wise | Chief Commercial Officer | 25 May 2023 | 3,366 | 102,681 (0%) | 0% | 19.0 | 63,786 | Common Stock | |
| Melvin Sharoky | Director | Purchase of securities on an exchange or from another person at price $ 19.29 per share. | 15 May 2023 | 10,000 | 298,615 (0%) | 0% | 19.3 | 192,900 | Common Stock |
| Melvin Sharoky | Director | Purchase of securities on an exchange or from another person at price $ 19.29 per share. | 15 May 2023 | 10,000 | 10,000 (0%) | 0% | 19.3 | 192,900 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 19.22 per share. | 15 May 2023 | 1,830 | 96,714 (0%) | 0% | 19.2 | 35,173 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 18.45 per share. | 15 May 2023 | 1,217 | 95,497 (0%) | 0% | 18.5 | 22,454 | Common Stock |
| S. Nicole Schaeffer | Chief People Strategy Officer | Sale of securities on an exchange or to another person at price $ 18.16 per share. | 15 May 2023 | 1,972 | 93,525 (0%) | 0% | 18.2 | 35,812 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 18.41 per share. | 15 May 2023 | 3,714 | 348,444 (0%) | 0% | 18.4 | 68,375 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 18.12 per share. | 15 May 2023 | 7,099 | 341,345 (0%) | 0% | 18.1 | 128,634 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Sale of securities on an exchange or to another person at price $ 19.23 per share. | 15 May 2023 | 6,048 | 352,158 (0%) | 0% | 19.2 | 116,303 | Common Stock |
| Sara Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 18.47 per share. | 15 May 2023 | 1,610 | 117,619 (0%) | 0% | 18.5 | 29,737 | Common Stock |
| Sara Bonstein | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.30 per share. | 15 May 2023 | 2,210 | 119,229 (0%) | 0% | 19.3 | 42,653 | Common Stock |
| Drayton Wise | Chief Commercial Officer | 15 May 2023 | 381 | 107,960 (0%) | 0% | 18.4 | 7,026 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 15 May 2023 | 593 | 108,341 (0%) | 0% | 19.3 | 11,439 | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 15 May 2023 | 1,913 | 106,047 (0%) | 0% | 18.2 | 34,759 | Common Stock | |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.39 per share. | 15 May 2023 | 1,521 | 162,781 (0%) | 0% | 18.4 | 27,971 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 19.27 per share. | 15 May 2023 | 2,847 | 164,302 (0%) | 0% | 19.3 | 54,862 | Common Stock |
| Roger Adsett | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 18.12 per share. | 15 May 2023 | 2,448 | 160,333 (0%) | 0% | 18.1 | 44,358 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.43 per share. | 15 May 2023 | 1,718 | 114,906 (0%) | 0% | 18.4 | 31,663 | Common Stock |
| Martina Flammer | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 19.28 per share. | 15 May 2023 | 2,576 | 116,624 (0%) | 0% | 19.3 | 49,665 | Common Stock |
| Michael Smith | General Counsel, Senior VP | Sale of securities on an exchange or to another person at price $ 18.43 per share. | 15 May 2023 | 475 | 78,345 (0%) | 0% | 18.4 | 8,754 | Common Stock |
| Michael Smith | General Counsel, Senior VP | Sale of securities on an exchange or to another person at price $ 18.18 per share. | 15 May 2023 | 1,263 | 77,082 (0%) | 0% | 18.2 | 22,961 | Common Stock |
| Michael Smith | General Counsel, Senior VP | Sale of securities on an exchange or to another person at price $ 19.24 per share. | 15 May 2023 | 1,897 | 78,820 (0%) | 0% | 19.2 | 36,498 | Common Stock |
| Alfred F. Altomari | Director | 11 May 2023 | 13,192 | 56,333 (0%) | 0% | - | Common Stock | ||
| Carol A. Schafer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 13,192 | 45,097 (0%) | 0% | - | Common Stock | |
| David W.J. McGirr | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 13,192 | 85,753 (0%) | 0% | - | Common Stock | |
| Melvin Sharoky | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 13,192 | 290,415 (0%) | 0% | - | Common Stock | |
| Melvin Sharoky | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 May 2023 | 1,800 | 288,615 (0%) | 0% | 0 | Common Stock | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 121,850 | 121,850 | - | - | Stock Option (right to buy) | |
| S. Nicole Schaeffer | Chief People Strategy Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 26,385 | 98,544 (0%) | 0% | - | Common Stock | |
| David R Brennan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 13,192 | 108,713 (0%) | 0% | - | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2023 | 83,334 | 0 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2023 | 83,333 | 0 | - | - | Stock Option | |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 93,139 | 358,206 (0%) | 0% | - | Common Stock | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.44 per share. | 11 May 2023 | 67,257 | 67,257 (0%) | 0% | 12.4 | 836,677 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.44 per share. | 11 May 2023 | 83,333 | 150,590 (0%) | 0% | 12.4 | 1,036,663 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.44 per share. | 11 May 2023 | 83,334 | 233,924 (0%) | 0% | 12.4 | 1,036,675 | Common Stock |
| William H. Lewis | Director, Chair and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 430,140 | 430,140 | - | - | Stock Option (right to buy) | |
| William H. Lewis | Director, Chair and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2023 | 67,257 | 0 | - | - | Stock Option (right to buy) | |
| Sara Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 158,410 | 158,410 | - | - | Common Stock | |
| Sara Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 21,108 | 121,439 (0%) | 0% | - | Common Stock | |
| Sara Bonstein | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 34,300 | 100,331 (0%) | 0% | - | Common Stock | |
| Drayton Wise | Chief Commercial Officer | 11 May 2023 | 31,662 | 108,934 (0%) | 0% | - | Common Stock | ||
| Drayton Wise | Chief Commercial Officer | 11 May 2023 | 146,220 | 146,220 | - | - | Stock Option (right to buy) | ||
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 146,220 | 146,220 | - | - | Common Stock | |
| Roger Adsett | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 31,662 | 167,149 (0%) | 0% | - | Common Stock | |
| Clarissa Desjardins | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 13,192 | 48,787 (0%) | 0% | - | Common Stock | |
| Leo Lee | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 13,192 | 111,457 (0%) | 0% | - | Common Stock | |
| Elizabeth McKee Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 13,192 | 55,509 (0%) | 0% | - | Common Stock |